What is the significance of a mole on the head in astrology? Answer (1 of 2): Hi Gautam Hegde. Thanx for the A2A. Do let me know if the mole is on the right side or on the left side of the head, because the result will vary accordingly. If it is on the right side of the head, then such a person is very fortunate, a leader of the masses and is lucky in all ...